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  Pomalidomide (CC-4047) is redefining experimental paradigms in hematological malignancy research, enabling precise tumor microenvironment modulation and potent cytokine inhibition. Its versatility extends from high-content myeloma cell line screening to erythroid differentiation studies, making it essential for next-generation translational workflows.

• Pepstatin A: Aspartic Protease Inhibitor in Viral and Bon...

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  Pepstatin A redefines experimental precision in viral protein processing and osteoclast differentiation studies by offering potent, selective inhibition of aspartic proteases. Its optimized workflow integration and troubleshooting strategies accelerate discovery in immunopathology, making it indispensable for advanced cell culture and infection models.

• DRB: A Powerful Transcriptional Elongation Inhibitor for ...

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  Unlock the full research potential of DRB (5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole)—a gold-standard transcriptional elongation and CDK inhibitor. Discover optimized protocols, advanced use-cases in HIV and cell fate studies, and robust troubleshooting strategies for maximizing experimental success.

• Panobinostat (LBH589): Epigenetic Engineering and Apoptos...

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  Explore how Panobinostat (LBH589), a broad-spectrum hydroxamic acid-based histone deacetylase inhibitor, uniquely advances epigenetic regulation research by linking HDAC inhibition to novel apoptosis pathways. Discover a fresh, mechanistic perspective on cell death in cancer biology.

• EZ Cap™ Firefly Luciferase mRNA: Engineering Next-Level m...

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  Explore how EZ Cap™ Firefly Luciferase mRNA with Cap 1 structure advances mRNA delivery, stability, and ATP-dependent D-luciferin oxidation for robust bioluminescent reporter assays. This article uniquely dissects molecular engineering strategies underpinning enhanced transcription efficiency and in vivo imaging applications.

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• We next considered the effect of

  2025-03-03

  

  We next considered the effect of alkyl chain length on the inhibitory activity. As can be seen from , it is obvious that there is no proportional relationship between the methylene chain length and activity. The activity decreased when the chain length increased from 1 to 3 and increased with elonga

• In our previous study we showed that normal

  2025-03-03

  

  In our previous study we showed that normal and cancerous rad51 of kidney exhibit the activity of alcohol dehydrogenase and aldehyde dehydrogenase. Furthermore, the activity of class I ADH isoenzymes and total ADH were significantly higher in cancer tissue than in unchanged renal cells. Moreover, t

• Heart failure is a chronic syndrome in which

  2025-03-03

  

  Heart failure is a chronic syndrome in which the heart is unable of pumping an adequate supply of blood to meet the metabolic requirements of the body or generating the required elevated ventricular filling pressures to maintain output [34]. Despite considerable advances in the treatment of heart fa

• br Experimental section br Results

  2025-03-03

  

  Experimental section Results and discussion Conclusions We present a simple, sensitive and selective assay of ADA activity and its inhibitor using the enzyme catalyzed reaction and the different interaction intensity of dye-labeled AD aptamer, aptamer/AD complex with GO. The as-proposed met

• This study was funded and

  2025-03-03

  

  This study was funded and supported by Tehran University of Medical Sciences and Health Services; and Iran National Science Foundation. Introduction The enzyme acetylcholinesterase (AChE) plays a central role in the signal transduction in the nervous system, hydrolyzing the neurotransmitter acet

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