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Apple juice is the most consumed apple derivative since more
2022-08-17
Apple juice is the most consumed apple derivative since more than 20% of freshly harvested apples are consumed as juice (Schulze et al., 2014). Apple juice production implies several technological interventions, among which are skin and pomace removal, enzymatic depectinization, and pasteurization.
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Ghsr may have therapeutic value in disorders associated with
2022-08-17
Ghsr may have therapeutic value in disorders associated with impairments in AHN. As anxiety disorders and enhanced fear responses observed in PTSD are linked with overgeneralization of similar but distinct memories (i.e poor discrimination), we suggest that acyl-ghrelin’s anti-anxiety effect (Lutter
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Although drug monitoring is not usually
2022-08-16
Although drug monitoring is not usually requested, there are some cases where measurement of DOACs in chenodeoxycholic acid synthesis is useful, and of special help for managing patients at risk. These cases include the control of adherence to a therapeutic protocol, surveillance of drug accumulati
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Biliary tract cancers BTC are categorized into intrahepatic
2022-08-16
Biliary tract cancers (BTC) are categorized into intrahepatic, perihilar, extrahepatic BTC (or cholangiocarcinoma) as well as gallbladder cancer (GBC). Although the incidence of BTC is low in developed countries (3% of gastrointestinal cancers), BTC is the second most common primary liver tumor afte
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STAR Methods br Acknowledgments We
2022-08-16
STAR★Methods Acknowledgments We thank C. Hong, R. Huang, and Z. Yu at the HHMI Janelia cryo-EM facility for help with microscope operation and data collection. We thank A. Müller, W. Kan, and W. Weis for help with the SEC-MALS analysis and M. Elazar and J. Glenn for the use of equipment. P. Love
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Protease Inhibitor Library br Since viral infections result
2022-08-15
Since viral infections result in polarization of naïve CD4 T cells into both Th1 and Tfh subsets (although to variable degrees depending on the nature of the pathogen), a lot of effort has been devolved to the question of whether type I IFNs play a role in CD4+ T cell polarization. In vitro studie
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br Methods br Results br Discussion
2022-08-13
Methods Results Discussion In this study, we investigated temperature effects on Vj-gating properties of two cardiac GJs. In the case of Cx45 GJs, increased temperature from 22 °C to 28 °C (or 32 °C) led to an accelerated Vj-dependent deactivation with little change in the extent of Vj-gati
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L-161,982 br FPRs regulate anti microbial
2022-08-13
FPRs regulate anti-microbial responses The classic evidence supporting FPR as an anti-microbial receptor is that bacteria are the major biological source of chemotactic formyl peptides, fMLF binds to FPR and fMLF activates chemotactic and anti-microbial responses in neutrophils 2., 3.. Recently,
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As a part of our
2022-08-13
As a part of our continuing efforts towards discovery of new class of compounds against different therapeutic areas and based on the literature reports, we designed a dual pharmacophore which possess a long aliphatic chain of free fatty acids and a phenyl propanoid part of known GPR40 agonists. Here
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Several transgenic and knockout congenic mouse models have
2022-08-13
Several transgenic and knockout/congenic mouse models have been generated in order to assess the role of FFAR1 for proper insulin secretion and maintenance of glucose homeostasis. The results obtained with three different receptor knockout mouse models were not consistent. The protection against hig
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br Conclusions and perspectives In
2022-08-13
Conclusions and perspectives In conclusion, offering duly validated and highly performing assays for measuring DiXaIs in plasma is a step, but not the final issue. More dedicated and individual assays will continue this innovative development, which witnesses the need for collaboration between co
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br Methods br Results br Discussion In the general populatio
2022-08-13
Methods Results Discussion In the general population BNP has been established as a marker for CGP 55845 hydrochloride sale failure diagnosis. Moreover, there is growing evidence that elevated levels of natriuretic-peptides may improve CV risk prediction in the general population above trad
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In NAFLD models the first hit is
2022-08-13
In NAFLD models, the “first hit” is liver fat accumulation, which causes insulin resistance, whereas the interplay of inflammatory cytokines, which causes inflammation, acts as the representative “second hit” [9]. However, recently, the “multiple hit” hypothesis has taken into consideration that mul
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Treatment with histamine had no
2022-08-13
Treatment with histamine had no effect on histamine H1 receptor expression in HepG2 Flavin adenine dinucleotide (Fig. 1), while knockdown of histamine H1 receptor expression prevented histamine from repressing apo A-I gene expression (Fig. 2). Overexpression of the histamine H1 receptor regulated a
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Based on pharmacophore modeling a good HDAC inhibitor has at
2022-08-12
Based on pharmacophore modeling, a good HDAC inhibitor has at least three sides/regions: the attachment side of the Zn2+ cofactor/HDAC active site (Zn2+ binding group/ZBG), hydrophobic cap (CAP) and linker containing connecting unit (CU) with electronegative groups (Mohan et al., 2011, Rossi et al.,
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