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In conclusion we have shown that the
2022-05-09
In conclusion, we have shown that the brain penetrating ability of heteroaryl piperazine and piperadine ureas can be modulated through small structural changes to the heteroarenes, the piperazine or piperidine core, and the biaryl ether tail. Compounds exhibiting / ratios ranging as high as 4.2:1 to
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AD is a major neurological disorder usually effecting the
2022-05-09
AD is a major neurological disorder, usually effecting the elderly population, which is difficult to diagnose until symptoms begin to accumulate. As of 2013, approximately five million Americans were living with AD. The number with this disease is projected to be 16 million by 2050 (Hebert et al., 2
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Syringe services programs SSPs as well as expanded HIV
2022-05-09
Syringe services programs (SSPs), as well as expanded HIV and hepatitis C virus (HCV) testing, are key components of harm reduction for PWID and can reduce HIV and hepatitis C virus (HCV) transmissions in this Preladenant [14], [15], [16]. The number of SSPs has increased in recent years in West Vi
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In conclusions it is hypothesized that
2022-05-09
In conclusions, it is hypothesized that caffeine administration could lead to an increase in histamine neuronal activation or release of histamine [38] to induced locomotor stimulation via H1 receptor activation. In addition, the present study also propose that the spaced administration of caffeine
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The central region of Azalanstat can be substituted
2022-05-09
The central region of Azalanstat can be substituted with connecting alkyl chains of different nature and length. Interesting results were given by compounds with a four or five Pridinol Methanesulfonate chain, incorporating heteroatoms, such as oxygen (Fig. 2, compound 4) or sulfur, and different f
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br Methods br Results br Discussion TA
2022-05-09
Methods Results Discussion TA-TMA is a severe complication for patients after HSCT. The pathogenesis of TA-TMA is unclear. Complement activation and endothelial cell injury may be involved in the pathogenesis of TA-TMA. Our previous investigations had demonstrated that plasma levels of C5b-
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br The hedgehog signalling pathway The canonical Hh
2022-05-09
The hedgehog signalling pathway The canonical Hh pathway is a conserved, highly complex signalling cascade, with many players and intricate regulation. However, it can be simplified into four fundamental components: i) the ligand Hh, ii) the receptor Patched (Patch [PTCH1]), iii) the signal trans
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The PAS and CC domains of sGC
2022-05-09
The PAS and CC domains of sGC have been studied less by comparison, though their function in sGC signal transduction is likely important. PAS domains are versatile as they can play varied roles in different proteins, such as quaternary structure organization, cofactor binding, and signal transductio
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br Materials and methods br Results br Discussion In
2022-05-07
Materials and methods Results Discussion In this study, we demonstrated that zaprinast (a cGMP-PDE inhibitor) induced the intracellular calcium mobilization in the Y-27632 coexpressing GPR35 and Gqi5, Gqo5, or Gα16. Induction of intracellular calcium mobilization by zaprinast in the GPR35-e
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Consistent with previous reports of
2022-05-07
Consistent with previous reports of an association between increased accumulation of cAMP and GLP-1 secretion [25, 44, 45], we hypothesized that Oleoyl-LPI may regulate GPR119 activation and secretion of GLP-1 secretion through the cAMP/PKA/CREB pathway. Pharmacological inhibition of PKA by H-89 was
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br STAR Methods br Introduction
2022-05-07
STAR★Methods Introduction Glycosylation is one of the most prevalent post-translational modifications of proteins. It not only plays major roles in folding, transport and localization of proteins [1], but also regulates various biological processes such as cell growth, viral replication and im
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Given that we planned to isolate the GluN GluN A
2022-05-07
Given that we planned to isolate the GluN1/GluN3A receptor by immunoaffinity chromatography using a Myc epitope tag on GluN3A, we first checked that the tag does not affect the functional properties of the receptor. To do this we co-transfected HEK-293 cells with DNA encoding WT GluN1 and either WT
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br Materials and methods br Results br Discussion
2022-05-07
Materials and methods Results Discussion The glucose transporter GLUT1 can be acutely activated or inhibited in L929 fibroblast GDC-0068 sale by a wide variety of reagents or nutrient conditions [[9], [10], [11], [12],36,50]. This abrupt change in the activity of GLUT1 occurs within minute
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br Materials and methods br Acknowledgments br
2022-05-07
Materials and methods Acknowledgments Introduction Gentiooligosaccharides are novel functional oligosaccharides composed of glucose units linked through β-1,6 glycosidic bonds, examples of which include gentiobiose, gentiotriose and gentiotetraose (Barreteau et al., 2006, Kim et al., 2003,
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GK also called hexokinase IV or
2022-05-07
GK, also called hexokinase IV or D, is a glycolytic enzyme that converts Chromocarb to glucose-6-phosphate. GK has unique characteristics compared with those of the ubiquitously expressed hexokinase isoforms I–III, and is predominantly expressed in the pancreas and liver. In pancreatic β-cells, GK r
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