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br Introduction The brain contains abundant fatty acids
2022-04-19
Introduction The brain contains abundant fatty acids, which serve as constituents of membranes and as an energy source. In addition, fatty acids and their metabolites contribute to signal transduction between neurons or neurons and glial cells, suggesting that fatty acids play a crucial role in d
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br Results br Discussion Previous studies have shown
2022-04-19
Results Discussion Previous studies have shown that all the components of ET system are expressed by various neuronal and non-neuronal structures throughout the CNS (McCumber et al., 1990; Giaid et al., 1991). In effect, endothelin-converting enzyme activity, mRNA, ET-1 and ET-3 immunoreactivi
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br Drugs approved or in development
2022-04-19
Drugs approved or in development To date, three drugs: RAL (MK-0518), EVG (GS-9137) and DTG (GSK1349572) [104], have been approved by the FDA. Their structures are shown in Fig. 5. DTG is under development by GlaxoSmithKline (GSK), and studies have shown DTG to be effective in patients with resis
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Production of reactive oxygen species ROS at the site
2022-04-19
Production of reactive oxygen species (ROS) at the site of pathogen attack following recognition of pathogen-associated molecular patterns (PAMPs) is regarded as one of the initial plant immune responses. ROS accumulation can induce a hypersensitive reaction in host plants, thereby causing programme
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Two typical properties of Gi o protein coupled receptors
2022-04-19
Two typical properties of Gi/o protein-coupled receptors, namely an increase in 35S-GTPγS binding (Strange, 2010) and an inhibition of exocytotic noradrenaline release (Schlicker and Göthert, 1998), were not shared by H4 receptor activation on cortical membranes (guinea-pig and mouse) and cortical s
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br Material and methods br Results br Discussion
2022-04-19
Material and methods Results Discussion In vitro testing is necessary to study DAA activity and putative RASs. Compared to enzymatic assays and replicons, HCV infectious culture systems reflect the full viral life cycle and previous results in these systems reflected clinical data.[13], [14
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Atractyloside Dipotassium Salt synthesis br Materials and me
2022-04-19
Materials and methods Results Discussion Genetic analyses conducted here were based on specific features of PhyChem indexes for nt dimers extracted to generate a numerical sequence representation, which was used to build models for distinguishing HVR1 variants between CIP and MIP. This data
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br Concluding remarks br Conflict of interest
2022-04-18
Concluding remarks Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements We thank all the present and former members in our laboratory for their contributions to
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Finally a potentially effective therapeutic approach is to
2022-04-18
Finally, a potentially effective therapeutic approach is to target the LDH enzymes that mediate bidirectional conversion of pyruvate into lactate. In particular, because LDHA is the predominant isoform expressed in glycolytic tumours, an array of LDHA-targeting compounds have been proposed and valid
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br Introduction In the treatment of patients with AIDS and
2022-04-18
Introduction In the treatment of patients with AIDS and human immunodeficiency virus type 1 (HIV-1), anti-retroviral therapy (ART), which uses anti-HIV drugs such as protease inhibitors, integrase inhibitors and reverse transferase inhibitors, has made a major contribution. There are still some s
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br Material and methods br Results br
2022-04-18
Material and methods Results Discussion Organisms have developed a variety of anti-glycation defense mechanisms. In endomorphin mg to the aldose-reductase-pathway or 2-oxoaldehyde dehydrogenase-pathway, the glyoxalase system is the only mechanism, which is not restricted to liver [19]. Thi
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To test our refinement protocol we considered a benchmark se
2022-04-18
To test our refinement protocol, we considered a benchmark set of 12 N-linked glycan-containing protein structures determined by X-ray crystallography at resolutions ranging between 1.9 Å and 3.5 Å and comprising a total of 133 glycan units. We identified four incorrect anomeric configurations and 2
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Introduction Adaptations in the metabolism of cancers contri
2022-04-18
Introduction Adaptations in the metabolism of cancers contribute to tumor survival and growth and present opportunities to develop novel therapeutic strategies (Kelloff et al., 2005, Som et al., 1980). In particular, glutamine metabolism plays such an important role in cancer growth that a phenome
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br Introduction Opioids have long been used
2022-04-18
Introduction Opioids have long been used in pain management [1]. However, their non-medical use has grown rapidly in the last few years. Hydrocodone (HYD) is one of the most widely used short-acting opioids; with over 136.7 million prescriptions in 2011 [2]. HYD is a semi-synthetic opioid used fo
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alkaline phosphatase inhibitor This study was approved by ou
2022-04-18
This study was approved by our institutional ethics committee, and informed consent was obtained from each participant or legal guardian. We performed whole-genome SNP genotyping in the one unaffected and two affected siblings by using the Illumina Human 610 Genotyping BeadChip panel, which interrog
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