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br Statistical analysis The mean standard deviation
2022-03-02
Statistical analysis The mean, standard deviation, median, range, frequency, and percentage were used for data description. The chi-square (x2) test was used for analyses the differences in categorical variables in the 2-way table. Overall survival (OS) was defined as the time interval between t
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br Summary br Acknowledgement br
2022-02-28
Summary Acknowledgement GR: A Nuclear Receptor with Widespread Physiological Impact GR, or NR3C1 (see Glossary), is a transcription factor (TF) that regulates gene expression in nearly every cell of the body. A member of the nuclear receptor (NR) superfamily, its ligand-binding domain confe
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br Materials and methods br
2022-02-28
Materials and methods Results Discussion In this study, we demonstrated, for the first time, that manipulation of AKR1D1 expression and activity is able to regulate glucocorticoid availability in liver and non-liver cell lines. AKR1D1 over-expression leads to increased glucocorticoid cleara
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Acknowledgements br Introduction Alzheimer s disease AD is a
2022-02-28
Acknowledgements Introduction Alzheimer's disease (AD) is a devastating neurodegenerative disorder and the leading cause of dementia. There is currently no treatment available to slow or halt disease progression. The underlying mechanisms of AD on the cell and molecular levels are still not comp
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Although drug monitoring is not usually requested there are
2022-02-28
Although drug monitoring is not usually requested, there are some cases where measurement of DOACs in guanfacine hcl is useful, and of special help for managing patients at risk. These cases include the control of adherence to a therapeutic protocol, surveillance of drug accumulation risk in long t
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143 93 br Nanoscale Cortical Actin Remodeling in Regulated
2022-02-28
Nanoscale Cortical Actin Remodeling in Regulated Exocytosis The network of cortical 143 93 is formed by numerous fine actin filaments, which are only about 10nm in diameter [52]. Although the microscale role of the cortical actin network in vesicle exocytosis is well established, the function of
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Apoptosis is one of critical toxic
2022-02-28
Apoptosis is one of critical toxic mechanisms of benzene metabolites. In this work, overexpression of HIF-1a could significantly reduce the increase in cell apoptosis caused by 40 μM BQ. At the meanwhile, anti-apoptotic protein Bcl-2 level was significantly elevated in HIF-1a overexpression cells th
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On the other hand after injury
2022-02-28
On the other hand, after injury of the adult heart, inflammatory monocytes are abundantly recruited to damaged myocardium and they differentiate into monocyte-derived macrophages (MDMs). They have strong proinflammatory phenotype and very limited capacity to promote angiogenesis and cardiomyocyte pr
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AP and NF B activation is inhibited by curcumin diferuloylme
2022-02-28
AP-1 [16], [17] and NF-κB activation is inhibited by curcumin (diferuloylmethane) [18], [19], the yellow component of Curcuma longa that gives curry its colour and flavour. Curcumin has shown anti-inflammatory and antioxidant properties [20], [21], [22], [23], [24], [25], [26] due to the inhibition
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br Introduction The replacement of a regular
2022-02-26
Introduction The replacement of a regular intake of healthy oils and fibres for a diet based substantially on high fat- and high sugar-content foods has had profound consequences for public health. These changes in the way that the populations of high income, particularly Western countries, manag
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Cerulenin While a role for YAP
2022-02-26
While a role for YAP/TAZ signaling in oligodendrocytes has not been described, these Cerulenin are also responsive to mechanical stimuli. OPC proliferation and migration can be altered by plating on substrates of varying stiffness [20], resulting in differentiation in a density-dependent manner. Pl
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br Discussion Naloxone and CTAP were able to
2022-02-26
Discussion Naloxone and CTAP were able to alter the febrile response induced by gp120. This effect was particularly evident during the initial hours following gp120 administration (90–210min). We also investigated the potential role of the delta-2 opioid receptor in gp120-induced fever. The delta
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quercetine Depending upon the varied habitats e
2022-02-26
Depending upon the varied habitats (e.g. soil, water, animal digestive tracts, etc.), microbes possess a diverse range of carbohydrate ABC transporters and metabolic pathways (Rodionov et al., 2013; Bräsen et al., 2014). Thermus thermophilus HB8, a thermophilic gram-negative bacterium dwelling in ho
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To further implicate the role of EAAT in morphine
2022-02-26
To further implicate the role of EAAT3 in morphine-induced place preference, the effects of morphine on EAAT3 Polyphyllin VII was determined. Interestingly, morphine increased EAAT3 protein expression in the plasma membrane of mPFC, nucleus accumbens and VTA but not in the hippocampus of wild-type m
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The Hedgehog Hh pathway is linked to
2022-02-26
The Hedgehog (Hh) pathway is linked to the development of several types of epithelial cancers (Rubin and de Sauvage, 2006). A paracrine mechanism has been implicated in CAF activation, with Hh ligands secreted by cancer cells activating the glioma-associated transcription factors (Gli) in surroundin
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