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The investigation in vitro revealed that aldolase
2021-10-29
The investigation in vitro revealed that aldolase, as well as FBPase, has affinity to α-actinin, one of the structural protein of the Z-line (Rakus et al., 2003a, Mamczur et al., 2005). Therefore, the existence of in vivo heterologous complex, consisting of aldolase, FBPase and α-actinin has been po
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The translational relevance of our
2021-10-29
The translational relevance of our findings remains uncertain at this point. On the one hand, there have been reports to suggest that boosting KDM4 activity may engender beneficial effects in vivo. For instance, Li et al. have show that KDM4 interacts with β-catenin to mediate Wnt signaling in hepat
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To identify genes with significant expression differences we
2021-10-29
To identify genes with significant Rose Bengal differences, we performed differential gene expression analysis between the two individuals with TRRAP variants (combined as biological replicates) and two unaffected controls. Gene ontology (GO) enrichment analysis of these genes with the GOrilla web
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Classically HIF levels and consequently HIF transcriptional
2021-10-29
Classically HIF-α levels and consequently HIF transcriptional activity have been associated with hypoxic conditions. However, some years ago, regulation by hormones of HIF transcriptional activity under normoxic conditions was demonstrated. Different stimuli such as heregulin, IGF1 and insulin, amon
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PLP has been found to be effective inhibitor
2021-10-28
PLP has been found to be effective inhibitor of many enzymes that have Triflusal for phosphate-containing substrates or effectors, including RNA polymerase [14], [15], reverse transcriptase [16], and DNA polymerase [17], [18]. Oka et al. [19], [20] reported that vitamin B6 deficiency generally enha
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These agents can be divided into three categories based
2021-10-28
These agents can be divided into three categories based upon the therapeutic agent conjugated to the antibody; the most frequently explored are ADCs using a cytotoxic agent to be delivered directly to the tumor site. The second class has not been broadly used and consists of radionucleotides (Wong e
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The involvement of prostaglandins on
2021-10-28
The involvement of prostaglandins on the effects induced by 1-nitro-2-phenylethane is similarly unlikely because vasorelaxation was not changed by indomethacin [20]. The inhibition of adenylyl cyclase with MDL-12330A [21] or cAMP-dependent protein kinase A with KT-5720 [22] also did not interfere wi
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Previous studies have shown that Cu I neurotoxicity includes
2021-10-28
Previous studies have shown that Cu(I) neurotoxicity includes induction of ROS with involvement of the NF-kB pathway and apoptosis (Butterworth, 2010) and that, in its Cu(I) state, Cu(I) alters microglia phenotype and inhibits nitric oxide release (Rossi-George et al., 2012). Cu(I) has a great affin
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Using expression of TcMYH fused to GFP it was observed
2021-10-28
Using expression of TcMYH fused to GFP, it was observed that MYH is present in the nucleus and in the mitochondrion of T. cruzi (Fig. 5). It is known that MYH protein from human, rat and mouse exhibits both mitochondrial and nuclear localization (Ichinoe et al., 2004, Lee et al., 2004, Nishioka et a
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To further implicate the role of EAAT in morphine
2021-10-28
To further implicate the role of EAAT3 in morphine-induced place preference, the effects of morphine on EAAT3 Fluorescein-12-dUTP was determined. Interestingly, morphine increased EAAT3 protein expression in the plasma membrane of mPFC, nucleus accumbens and VTA but not in the hippocampus of wild-ty
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Cx mimetic peptides short synthetic peptides corresponding t
2021-10-28
Cx mimetic peptides, short synthetic peptides corresponding to intracellular amino PNU 37883 hydrochloride sequences of diverse Cx have better specificity compared to traditional GJ blockers and openers. In particular, it was reported that Cx mimetic peptides reversibly inhibited GJ channel functio
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In sharp contrast to these genetically altered animals there
2021-10-28
In sharp contrast to these genetically altered animals, there are two types of living fish that appear to lack Band 3 in their red blood cells. These are the Lamprey [45] and the Hagfish [46,47]. While these fish normally occupy their respective niches, the presumed compensatory mechanisms, as with
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Subsequently BAs are secreted in the portal vein by
2021-10-28
Subsequently, BAs are secreted in the portal vein by the heterodimeric organic solute transporter OSTα/β [15]. At this level, BAs are transported back to the liver, where the great majority is reabsorbed by the sodium (Na)-Taurocholate Cotransporter Protein (NTCP) and organic anion transporting poly
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Species specificity of small molecular GPR agonists have
2021-10-28
Species specificity of small molecular GPR40 agonists have been reported by Takeda scientist. In the binding pocket of TM5, a Leu186 in human GPR40/FFA1 is replaced with Phe in rat, resulting in dramatic inter-species GPR40 activity discrepancy in certain scaffolds of small molecular GPR40 agonists.
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HCC metastasis is a multistep multifactorial process
2021-10-28
HCC metastasis is a multistep, multifactorial process, including adhesion of tumor cudc 907 to the extracellular matrix (ECM), remodeling and degradation of ECM, invasion through local tissue, intravasation into blood or lymph vessels, and forming new tumors at distant sites [6,7]. Loss of adhesion
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