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In order to get a better understanding of this
2024-05-27
In order to get a better understanding of this synergy, we tested the effect of preliminary incubation of AG-490 with non-stimulating concentrations of gonadotropins or FSK before subsequent stimulation by FSK or gonadotropins alone, also at sub-stimulating concentrations. We observed that human LH
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In another study authors found that ADORA
2024-05-27
In another study, authors found that ADORA1 were present on the intrinsically photosensitive retinal ganglion epz (ipRGCs), and application of adenosine to rat retinas reduced light-evoked spiking of ipRGCs through suppression of a cAMP-mediated pathway (Sodhi and Hartwick, 2014). The ipRGCs are a
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br Materials and methods br Results
2024-05-27
Materials and methods Results Discussion In the present study, we aimed to elucidate the contribution of adenosine receptors to vascular tone in mice with T1D. We showed that diabetes resulted in decreased A1 adenosine receptor-mediated contraction in the aorta, which was accompanied by inc
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As an alternative to chronic
2024-05-27
As an alternative to chronic receptor blockade, we have been targeting adenosine kinase (ADK) – an astrocyte-based enzyme that catalyses the phosphorylation of adenosine, as a means to modify lorlatinib adenosinergic signalling (Boison, 2006, Etherington et al., 2009). Up-regulating ADK facilitates
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Qualitative inspection of the single channel
2024-05-27
Qualitative inspection of the single-channel traces presented in both Figures 3 and 4 shows that within bursts of activity, βAnc-containing AChRs display a marked reduction in open probability. To quantify these differences in single-channel behavior, we performed dwell-time analysis under high-reso
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Altogether the situations described above clearly impede the
2024-05-27
Altogether, the situations described above clearly impede the critical steps of drug discovery and development and the scientific process in general [14]. In conclusion, it is the opinion of these authors that many exciting lines of drug discovery (which includes those devoted to nAChR ligands) have
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Because activation of HT A receptor is capable of facilitati
2024-05-27
Because activation of 5-HT2A receptor is capable of facilitating dopamine cell activity and dopamine release (Bortolozzi et al., 2003), and this action of dopamine is known to mediate rat maternal behavior, especially maternal motivation (Afonso et al., 2007, Febo et al., 2010, Li and Fleming, 2003,
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br Materials and methods br Results
2024-05-25
Materials and methods Results Discussions Our results indicated that autophagy was suppressed in GECs under HAGG treatment, through Akt/mTOR-dependent pathways. Previous reports provided clues for the linkages between ICs and endothelial cell autophagy. Fujii and colleagues reported that se
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Aurora A overexpression is also related to the activation of
2024-05-25
Aurora-A overexpression is also related to the activation of NF-κB, a potent anti-apoptotic effector that may play a role in preventing apoptosis in cancer Gliotoxin [18]. These data show that we are still at the beginning of unraveling the complex mechanism by which these gene products and protein
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moxalactam mg There are two major isoforms of LO in
2024-05-25
There are two major isoforms of 12/15-LO in mammalian, 12 and 15- LO, with different cellular distributions. To determine the relative contributions of these isoforms towards glucose-induced monocyte-endothelial interactions, the distribution of these isoforms in the two cell types involved in leuko
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Resiniferatoxin Finally not only can ERs pair with different
2024-05-25
Finally, not only can ERs pair with different mGluRs in different Resiniferatoxin regions, but it is becoming increasingly clear that the same mGluRs can pair with distinct downstream signaling partners to have differential effects both within and across brain regions (Gross et al., 2016; Mannaioni
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br Acknowledgements M M M is the William Dow Lovett
2024-05-25
Acknowledgements M.M.M. is the William Dow Lovett Professor of Neurology and is supported by grants from the Michael J. Fox Foundation for Parkinson's Research, the American Parkinson Disease Association, the New Jersey Health Foundation/Nicholson Foundation, and by the National Institutes of Hea
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ARG I is one of the most important mammalian enzymes
2024-05-25
ARG I is one of the most important mammalian enzymes responsible for nitrogen metabolism since it comprises the main route for the elimination of excess nitrogen resulting from amino 7867 and nucleotide metabolism [18]. ARG I deficiency leads to hyperargininemia, characterized by progressive neurol
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Autophagy and apoptosis have a very complex relationship
2024-05-25
Autophagy and apoptosis have a very complex relationship, and the precise mechanism remains to be determined. At present, a large amount of research has confirmed that autophagy can protect the cell from apoptosis in special conditions such as nutrient deficiency or growth factors deprivation; the e
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The objectives of this study were
2024-05-25
The objectives of this study were to investigate 1) the mRNA and protein expression of apelin and APJ in porcine ovarian follicles of different sizes, and their immunolocalization and concentrations in follicular fluid and ovarian follicle, and 2) the direct effect of recombinant human apelin-13 on
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