• In conclusion our results provide

  2020-01-10

  

  In conclusion, our results provide a new mechanistic insight into the signaling pathways mediating TDCIPP-induced apoptosis in cultured neuronal cells. We showed that TDCIPP-induced neuronal cell cytotoxicity and death are mediated via the ER stress-regulated apoptotic pathway, wherein the induction

• The best preserved individuals were selected for isotope

  2020-01-09

  

  The best preserved individuals were selected for isotope analysis of diet (Table 2). These represent 21 individuals including four subadults: two young children aged between 1.5 and 2.5 years old, one child between 7 and 11 years old and one adolescent (12–16 years old), and 17 adults including six

• Despite many studies having demonstrated

  2020-01-09

  

  Despite many studies having demonstrated the importance of connexin43 (Cx43), the most abundant connexin in bone cells, for bone development and turnover during the last decade [27], little is currently known about GJIC and Cx43 in primary bone tumors. In this report, we analyzed the specific role o

• Enolase is an example of

  2020-01-09

  

  Enolase is an example of a moonlighting protein that displays multiple biological actions, including plasminogen, laminin, fibronectin, mucin and cytokeratin binding properties. It has also been described as a complement-evasion protein and as a protein capable of inducing neutrophil trap formation

• DNA PK Jackson is activated

  2020-01-09

  

  DNA-PK (Jackson, 1997) is activated by DNA double-stranded breaks (DSBs). It is a trimeric complex composed of the catalytic subunit, DNA-PKcs, and the Ku70/80 heterodimer. DNA-PK mediates non-homologous end joining (NHEJ), which joins programmed DSBs created during V(D)J recombination and class swi

• In laboratory strains of Escherichia coli three mechanisms

  2020-01-09

  

  In laboratory strains of Escherichia coli, three mechanisms of repair for alkylated bases are known. The first involves constitutively expressed Ogt and inducible Ada methyltransferases, directly removing methyl groups from O6-methylguanine (O6meG) and O4-methylthymine (O4meT) [1], [2], [3], [4]. In

• Predictions of enzyme topology for DGAT are more

  2020-01-09

  

  Predictions of enzyme topology for DGAT2 are more difficult since the DGAT2 polypeptide sequences are more diverse across species than those of DGAT1. The length and function of the hydrophilic N-terminus preceding the first hydrophobic segment varies with species – for example, segments in fungi ar

• br Materials and methods br Results br Discussion

  2020-01-09

  

  Materials and methods Results Discussion In this study we characterized in more detail the interrelationship between the expression levels of the B. malayi Bm-cpl-3 and Bm-cpl-6 cysteine proteases and the fitness of Wolbachia, and consequently that of the parasite. Our present in vitro data

• Two parameters were extracted from

  2020-01-09

  

  Two parameters were extracted from these experiments to compare the interactions of the three compounds with ct-DNA. The association constant K for the binding of the naphthalimide derivatives to ct-DNA was calculated by fitting the evolution of the fluorescence spectra with a 1:1 binding model usin

• br Results br Discussion The results showed a surprising

  2020-01-09

  

  Results Discussion The results showed a surprising 93 6 of DNA in stains even at extreme environmental conditions (35–65 °C, 100% relative humidity), provided the stains had been dried prior to incubation. We had expected a rapid decay of DNA at high relative humidity but observed, on the con

• Ultrasound is an acoustic wave with a frequency

  2020-01-09

  

  Ultrasound is an acoustic wave with a frequency >20 kHz that needs a medium to propagate [20]. Accompanied by the spread of an ultrasonic wave, a series of alternating cycles of compression and rarefaction emerge in the liquid medium. During the rarefaction cycle, microbubbles are formed because of

• As the COMT enzyme is primarily related to prefrontal

  2020-01-08

  

  As the COMT enzyme is primarily related to prefrontal dopamine degradation (e.g., Yavich et al., 2007), the present study supports the notion that prefrontal dopamine modulates retention of fear extinction rather than within-session extinction (Abraham et al., 2014). Consistent with other studies we

• br Method br Results br Discussion

  2020-01-08

  

  Method Results Discussion In this cross-sectional study, we investigated the relationship between the COMT ValMet polymorphism and age on regional cortical thickness in healthy adults across the lifespan. The mesocortical pathway was of primary interest because of its projections from the v

• Namely the NOESY cross peaks between H methylene

  2020-01-08

  

  Namely, the NOESY cross-peaks between H-7″ methylene protons ( 4.01 and 4.16) with H-6′ ( 6.76) revealed that H-2 and OH-3 are -orientated, which indicated that the relative configuration of the C2 and C3 substituents as . For the -isomers, the thermodynamically more stable conformation is when H-2

• The use of the periplasmic fraction

  2020-01-08

  

  The use of the periplasmic fraction as starting material and the presence of a unique purification step concurred in improving the purification yield to 25.3%, which is significantly higher than what obtained with the previous purification protocol (6.7%). In addition, the analysis of the kinetic co

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