• Early studies demonstrated that primitive cells are readily

  2018-10-24

  

  Early studies demonstrated that primitive d-glucose are readily converted into iPSCs (Kim et al., 2008; Kleger et al., 2012; Tsai et al., 2011). Thus, we expected that Lgr5+ cells would be susceptible to reprogramming. Unexpectedly, Lgr5+ cells from HFs and MEFs showed more resistance to early repr

• br Materials and methods br Results br Discussion The presen

  2018-10-24

  

  Materials and methods Results Discussion The present study showed that CBL treatment enhanced the survival of grafted NSCs in APP tg mice. In contrast, in the vehicle-treated group there was decreased survival of transplanted neuroblasts that was worse in the APP tg mice. This is consistent

• br Materials and methods br Author

  2018-10-24

  

  Materials and methods Author disclosure statement Acknowledgments We are grateful to Prof. Angel Raya for his help and advice with iPS cell generation. This work was supported by grants from the “Centro de Investigación Biomédica en Red en Enfermedades Raras” (CIBERER) (grant 13-717/132.05

• br Introduction The grafting of

  2018-10-24

  

  Introduction The grafting of cultured keratinocytes to promote regeneration represents one of the oldest clinical examples of stem cell therapy (Green, 2008). The skin constitutes an essential barrier between the living tissues of the body and the external environment, and skin tissues have evolv

• Increased DA secretion from SZ hiPSC neurons is consistent w

  2018-10-24

  

  Increased DA secretion from SZ hiPSC neurons is consistent with the ability of current antipsychotics, functioning as D2 DA receptor antagonists, to ameliorate the positive symptoms of SZ (Seeman, 1987; Coyle and Konopask, 2012; Eyles et al., 2012). Interestingly, because current antipsychotics lack

• Introduction The NOD SCID Il

  2018-10-24

  

  Introduction The NOD.SCID Il2rγ (NSG) mouse strain dramatically improved investigators’ ability to study human hematopoietic stem cell (HSC) engraftment (Rongvaux et al., 2013; Shultz et al., 2005). The NSG strain combines a series of mutations that inhibit the host’s immune system by different mec

• In Stevens and colleagues found penta snRNP

  2018-10-24

  

  In 2002, Stevens and colleagues found penta-snRNP, which contains all five spliceosomal snRNAs and over 60 pre-mRNA splicing factors, in yeast. They proposed that penta-snRNP associates prior to pre-mRNA substrate binding rather than with the pre-mRNA based on the results of a stepwise addition of d

• In this study we transplanted human

  2018-10-24

  

  In this study, we transplanted human iHeps into the livers of Gunn rats. Proliferation of the transplanted order AL 8697 was induced by preconditioning a single liver lobe by hepatic X-irradiation (HIR). HIR enhances the engraftment of transplanted cells by transiently disrupting the sinusoidal end

• br Results br Discussion We established

  2018-10-24

  

  Results Discussion We established a method of 3D differentiation without feeder EZ Cap Reagent GG to generate hPSC-derived PAEC spheroids via isolated progenitor cells using CPM as a surface antigen, which is reportedly a biomarker of lung diseases, such as acute pneumonia and lung cancer (Dr

• Conversely not much is known

  2018-10-24

  

  Conversely, not much is known about the origin of these mutations. Their high frequency, combined with the proficient DNA repair of hESC (Sokolov and Neumann, 2013), suggests that these focal adhesion kinase undergo profuse DNA damage in culture. Studies on genetic mosaicism in hESC cultures, which

• FUS also known as Translocated in

  2018-10-24

  

  FUS, also known as Translocated in Liposarcoma (TLS), is a DNA/RNA-binding protein containing a glycine-rich region, an RNA recognition motif and a nuclear localization signal (Lattante et al., 2013; Yang et al., 2010). In FALS, more than 50 mutations in the FUS gene have been reported (Lattante et 

• In the present study we aimed to

  2018-10-24

  

  In the present study, we aimed to establish a combination therapy approach composed of cellular replacement by ESC-derived neural progenitors linked to BDNF supply. For this reason, we have generated BDNF-overexpressing mouse ESCs by knockin technology that display an enhanced neuronal and GABAergic

• br Experimental Procedures br Author Contributions br

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We thank Professor Tao Cheng at the State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC for generously providing the H1 line; Professor H. Suemori at the Laboratory of

• In summary our findings identified legumain as a

  2018-10-24

  

  In summary, our findings identified legumain as a “molecular switch” with opposing effects on bone and fat formation by hBMSCs through degradation of the ECM protein fibronectin (Figure 6F) and that altered expression of legumain in the bone microenvironment contributes to the pathophysiology of tra

• TSC haploinsufficient astrocytes presented a high proliferat

  2018-10-24

  

  TSC haploinsufficient astrocytes presented a high proliferation rate and an increased saturation density when compared with WT astrocytes. Similarly, the conditional disruption of TSC1 in astrocytes using a human GFAP-Cre system was shown to produce mice that presented with astrocytosis (Han and Sah

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