• In the present study we showed that

  2023-09-09

  

  In the present study, we showed that 15-LOX metabolites, which are the precursors of anti-inflammatory and pro-resolving lipid mediators, were decreased in the unaffected skin area of the OS model rats by comprehensive lipidomics analyses. Furthermore, subsequent microarray analyses demonstrated tha

• The presence of crown like

  2023-09-09

  

  The presence of crown-like structures and inflammatory factors in the breast of obese patients is associated with considerable changes in intracellular signaling and a profound cellular dysfunction. Secreted pro-inflammatory factors can directly promote breast carcinogenesis as they have been report

• Our surprising results show that AAD treated tumors adjacent

  2023-09-08

  

  Our surprising results show that AAD-treated tumors adjacent to adipose tissues and in steatotic liver continue to grow in the presence of a minimal number of microvessels. In non-adipose tumor models, the similar degree of vascular suppression is translated into marked suppression of tumor growth.

• The sequential behavioral approach used in

  2023-09-08

  

  The sequential behavioral approach used in the present study reinforced the involvement of the BDNF/TRKB system in the effect of losartan. In mice with dampened BDNF expression, losartan was no longer able to exert antidepressant-like effects. Similar to what was observed after losartan treatment, t

• br Experimental section br Introduction Microglia were

  2023-09-08

  

  Experimental section Introduction Microglia were discovered as a novel cell population in LDN193189 in 1933 by a Spanish physician and histologist Pío del Río-Hortega [1]. In the eye, scientists used Hortega's staining technique to label the microglia in the retinal outer plexiform layer (OPL

• br Introduction Epilepsy is characterized by spontaneous rec

  2023-09-08

  

  Introduction Epilepsy is characterized by spontaneous recurrent seizures and represents one of the most frequent neurological diseases affecting about 60 million people worldwide (McNamara, 1999). It is estimated that up to 50% of all cases are triggered by “initial precipitating injuries”, such

• The results show that a tonic action of

  2023-09-08

  

  The results show that a tonic action of ACh on respiration is lacking. However, it is clear that muscarinic cholinergic mechanisms can modulate both eupneic breathing and the cough reflex. When these mechanisms are brought into action is obscure and only tentative proposals can be advanced. ACh in t

• The ATX LPA signaling axis has been implicated in

  2023-09-08

  

  The ATX–LPA signaling “axis” [5] has been implicated in a perplexing variety of physiological and pathophysiological processes, including vascular and neural development [5], [26], [27], [28], [29], tumor progression and metastasis [30], [31], lymphocyte trafficking [22], bone development [32], neur

• br Conclusion br List of abbreviations br Acknowledgment The

  2023-09-08

  

  Conclusion List of abbreviations Acknowledgment The studies performed by our laboratory and presented in this review were supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan, (KAKENHI 17590618 [to H.I.] and KAKENHI 22249017 [to Y.Y.]), and the Japanese S

• br Materials and methods br Results br Discussion

  2023-09-08

  

  Materials and methods Results Discussion Recent studies have highlighted TMN 355 and autophagy as novel targets for the treatment of liver fibrosis [7,14]. In this study, we demonstrated that catalpol protected the rat liver from CCl4-caused injury and fibrogenesis in vivo and in vitro for

• br The future of cancer therapeutics with Aurora kinase

  2023-09-08

  

  The future of cancer therapeutics with Aurora kinase inhibitors Involvement of Aurora kinases in deregulating multiple tumor suppressor and oncogenic pathways together with the preclinical findings on the efficacy of Aurora kinase inhibitors in attenuating growth of tumor Kartogenin synthesis su

• The most likely explanation for the species differences in

  2023-09-07

  

  The most likely explanation for the species differences in aromatase distribution and the unique Fmoc-Lys(Dnp)-OH receptor distribution in humans is the unique location, size and highly elaborate organization of the human aromatase gene (e.g. Bulun et al., 2003). The human Cyp19 is a large gene loc

• Most human diseases e g

  2023-09-07

  

  Most human diseases (e.g., cancer, diabetes, and neurodegenerative diseases) are complex and multifactorial. Several investigations in the literature focused on new multi-target drug development, which implies active pharmacophores incorporation in one scaffold (Meunier, 2008, Lazar et al., 2004, Te

• br Antioxidant polymers conjugates Natural antioxidants are

  2023-09-07

  

  Antioxidant-polymers conjugates Natural antioxidants are usually used as a substitute for synthetics but some degradation phenomena could influence their applications. For example, ascorbic bottle as a natural antioxidant undergoes yellowish coloration as a result of oxidation [29]. Sing and Kapl

• HMGN proteins are subject to extensive

  2023-09-07

  

  HMGN proteins are subject to extensive post-translational modifications which influence both their mode of binding to dopamine hydrochloride and their functional activity. Like the other HMG protein families, HMGNs are substrates for many of the same enzymes that modify histone proteins (review in

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