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br Materials and methods br Results As
2020-01-21
Materials and methods Results As shown in Table 1, blood urea nitrogen and serum creatinine levels were significantly elevated at both 1st and 7th days of pyelonephritis, when compared with those of the control group (PMelatonin formation or intratubular neutrophils, while tubules showed mild
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Compounds were screened for their
2020-01-21
Compounds were screened for their activity against the hERG channel, with the 2,3-Cl compounds more active here than the 2,4-F compounds. The homopiperazine examples (, , , ) showed increased hERG activity relative to the corresponding piperazines. The cell data for the 6,7-dimethoxyquinoline compo
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br Prostaglandin D PGD is derived from
2020-01-21
Prostaglandin D (PGD) is derived from the metabolism of arachidonic Brassinolide by cyclooxygenases and downstream PGD synthases. In the immune system, PGD is mainly produced by mast cells but also although at lower levels, by macrophages and Th2 lymphocytes. PGD binds to three different receptor
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POE specialises Rogers definition of engineering to systems
2020-01-20
POE specialises Rogers\' definition of engineering [37] to systems engineering as: As such, systems engineering becomes a problem solving exercise, the problem being, given a physical environment E, to find the system S that AP26113 meets a real-world need N to the satisfaction of a group of stake
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eukaryotic initiation factor Inopportunely normal aging brin
2020-01-20
Inopportunely, normal aging brings about decreases in frontal D1 receptor densities and a gradual decline in postsynaptic markers of dopamine in striatal, neocortical, and limbic areas of the eukaryotic initiation factor (Bäckman et al., 2006, de Keyser et al., 1990, Karrer et al., 2017, Suhara et a
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Antioxidants such as SFN have
2020-01-20
Antioxidants such as SFN have been proposed to be chemopreventive agents to inhibit, delay or reverse the development of cancer (Bayat Mokhtari et al., 2018). SFN was shown in breast epithelial cell culture to suppress oxidative metabolism of E2/E1 and thus protect against estrogen-mediated DNA dama
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ion channels Currently according to Mielke and
2020-01-20
Currently, according to Mielke and colleagues [103], drugs with US Food and Drug Administration (FDA) approval for Alzheimer therapy include the following: galantamine (Razadyn®, 4aS,6R,8aS-5,6,9,10,11,12- hexahydro- 3-methoxy- 11-methyl- 4aH [1], benzofuro[3a,3,2-ef] [2] benzazepin- 6-ol), rivastig
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Here we report for the first time that EphB contains
2020-01-20
Here, we report for the first time that EphB4 contains two NLS sequences and localises to the nucleus. This is mediated via an importin-α pathway and we show that EphB4 could potentially have a direct role in gene regulation. These data provide new insight into Eph receptor localisation and action a
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Our results indicate an OT specific activation of
2020-01-20
Our results indicate an OT-specific activation of PKR that inactivates eIF2a and may, by this means, reduce protein translation by utilizing only select sensors and mediators of the UPR (i.e., avoiding significant PERK activation). Interferon is a PKR activator [32] that temporarily subdues cellular
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Our data supports the conclusion that the exonuclease
2020-01-20
Our data supports the conclusion that the exonuclease activity thought to be intrinsic to Artemis is not a component of the Artemis polypeptide. Many possibilities exist to explain the presence of the exonuclease activity in less-pure fractions of Artemis. It is possible that the exonuclease is simp
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br Conclusion The role of
2020-01-20
Conclusion The role of DNA-PK target in DNA DSB repair renders this regadenoson kinase of great medicinal interest in cancer chemotherapy especially the cancer types of linked to DNA defects. Due to the absence of 3D DNA-PK target structure, different ligand-based methods were applied for design
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As the angular structure of compound cannot be differentiate
2020-01-20
As the angular structure of compound cannot be differentiated from the linear structure by H NMR spectroscopy, a NOESY NMR experiment was performed to unambiguously characterize the regioselectivity of the final compound. In the linear compound , a signature correlation between the proton of the t
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Introduction Nucleic acids are polyanionic and their
2020-01-20
Introduction Nucleic acids are polyanionic and their negatively charged nucleotides allow the binding of cationic dyes, such as acridine orange (3,6-dimethylaminoacridine). Acridine orange (AO) was first synthesized in 1889, but its ability to bind nucleic acids was only reported in 1940, with grea
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br Materials and Methods br Acknowledgements br
2020-01-20
Materials and Methods Acknowledgements Introduction The extracellular matrix (ECM) is a dynamic structure that acts as a scaffold for the mechanical support of multicellular organisms. It is responsible for the organisation of different tissues and regulates critical events in development a
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br Conclusion br Introduction Interleukin IL is a
2020-01-20
Conclusion Introduction Interleukin (IL)-18 [1] is a member of the IL-1 cytokine family activating corner stones of inflammatory signaling, among others nuclear factor (NF)-κB and p38 mitogen-activated protein kinase. Striking similarities exist between IL-1β and IL-18 including processing by
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